I don't really get the argument that increasing the number of issues coming out would be more of a financial strain on some people, therefore they shouldn't do it. It's not really fair. You don't really have to pick every issue up as it comes out--you could always trade-wait and/or save up to buy the collections, which would take less time if the issues do start to come out more often and would also give you a more coherent reading experience than reading it week by week in the midst of other stuff. If they have the material and resources to do it, and they want to tell their story faster or tell more of it, why restrict them?
Maybe I'm too familiar with this world to be confused by all of these different stories coming out at the same time. By now I'm just used to rolling with it--hey, we're in 1944 with some Nazis in this one, in Utah in 1948 with the BPRD in that one, fighting mobsters in this other one... I don't mind the effort of fitting these stories into the larger narrative. They don't really clog the 'Hell on Earth' storyline for me since they aren't actually a part of it. They contribute to the main plot in significant ways, but they aren't the main plot themselves.
The present-day story is only restricted to one (now two) books, and it's really not that hard to keep track of what's going on in BPRD #100, 101, 102, 103... and Abe #1, #2, #3, etc. The other series add to it, but they're optional. Excellent reading that enriches the world as a whole, but is not totally required for enjoyment of BPRD. At least that's how I see it.