There....really isn't any Vertigo at the moment. Everything is either ending or near-ending. The exception is American Vampire, which I'd definitely recommend. It's Scott Snyder's break-out work and it's on hiatus right now, giving you plenty of time to catch up.
That said, if you're willing to pick up trades of older runs, Vertigo has some "must-reads" for any comics fan, as it was the place where many of the greatest writers in comics did their magnum opuses. Garth Ennis' Preacher, Warren Ellis' Transmetropolitan, Neil Gaiman's Sandman, Brian K. Vaughan's Y: the Last Man, Grant Morrison's Invisibles (Doom Patrol is great too!), Jason Aaron's Scalped, and Jeff Lemire's recently concluded Sweet Tooth. That's roughly my order of preference too, come to think of it.
Some will mention Brian Wood's DMZ and Bill Willingham's Fables, no doubt, and those books definitely meet the profile of being their best works. However, I felt that DMZ got slower and slower and preachier and preachier, with the main character getting progessively whinier. As for Fables, many, including myself, believe that Fables was fantastic for years, but then reached the series' natural end-point that it'd been building up to since issue 1. But Willingham just decided to keep going forever, and the series has never been as good. There are currently 18 (!) trades, but if you just treat vol. 11 as the final one, I'd probably include Fables in my list.
A lot of people would probably also mention Brian Azzarello's 100 Bullets (again, another big writer's best work). The only reason I left it off is because, well, I've somehow never read it. I have the first 5 volumes on my shelf and will get to them one day.
Yeah, The Unwritten is Vertigo's finest current book, and I think it compares favorably with the other greats.
I've heard rumors that we'll be hearing about a new wave of Vertigo books in the coming months, including Collider, which has been MIA.
I'm reading Jason Aaron's Scalped, I can't believe I missed out on this. Very well written, art is gritty and dark so an acquired taste but fits the story nicely.
He had said earlier he was planning another Vertigo project, but who knows if the plans changed.It's the main reason why I'll read anything Jason Aaron does, regardless of publisher or whatever. I devoured the first four trades during a heatwave, which was perfect, given how dusty and dirty the book feels. Aaron told me on Facebook right after Scalped ended that he's currently working on a creator-owned miniseries. He didn't say if it was going to be Vertigo though, only that he wanted to wait till it was further along before soliciting or announcing it.
I like Jason Aaron, but Wolverine and the X-Men has become a disappointment. I know people like Thor: GOT, but I can't stand that character.
I read the first issue, which was good, but I didn't think it was great the way people do here. I'm guessing it's gotten even better now?
As for previous Thor, I did think JMS's run was good. I've yet to read Kirby and Simonson's Thor runs - I feel like that's the kind of thing more up my alley.
Sandman Mystery Theatre
Seven Miles a Second
Brave Old World
Vertigo Pop: Tokyo & London
Skreemer (One of Milligan and Ewins's finest comic)
Can't Get No
The Tragical Comedy or Comical Tragedy of Mr. Punch
Saludos desde el exilio a una generaciůn de destructores.