With Orion featuring in this current story arc in Wonder Woman, I wondered if Azzarello might put a twist on the classic myth between Orion and Artemis.
Greek myth Orion is linked by love and death with Artemis, as well as Apollo (and Helios). Nu Orion has apparently visited Earth a time or two, so perhaps there can be a modern Nu-myth around these two characters.
Orion's (possible) friendliness or (possible) romantic interest in Wonder Woman might further irk Artemis, leading to round 2 between the goddess-sisters.
At least, that's how it plays out in the comic I'm writing in my head.