Not so much ignoring it but changing most of it back to the way it was (the Inhumans, Kree) or just changing it completly (Nova). Some stuff (Darkhawk and the Raptors, Badoon) will probably not be touched on again at all.
I don't know. Maybe Bendis will respect the previous run and not change up every character personality just to suit his style. Its hard to say. On the other hand Loeb never has cared anything about what came before him and is just going to do what he wants even if it does contadict past Nova stuff.
Of the two I am willing to give Bendis a shot. Loeb not a chance in hell.