Inexplicably, seeing the moment of the Universe's creation from within the Universe changes it dramatically.
So, when Krona saw a hand (Presumably that of the Presence, though it's never explained and no-one is there when A-M goes back to change it) through his time viewer, he broke the Universe into a Multiverse.
Basically, they made it so that Krona instead saw the interlocked hands of the Anti-Monitor and the Spectre, both struggling to be the only one visible.
A Flock of Sheep.
A Pack of Wolves.
An Inconvenience of Heroes.
Also, Spectre had to get juiced up to the point where he was screaming in pain just to stalemate Anti-Monitor.
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