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I would say that Superior Spider-Man is a clean entry point. The hook spoilers:
end of spoilers is easy to understand, and there's likely to be some new reader friendly exposition in the early issues, as spoilers:
(supervillain possesses superhero's body)
end of spoilers Although there is some long-time fan outrage.
Doc Ock gets used to his new status.
Hawkguy is the best.
I know Kevin Nichols through a guy that knows a gal. Small world!
If nihilism didn't take some delight in destruction one might suspect nihilists were an unnaturally morbid sort.
A good example are Thor and Hawkeye. I haven't read an Avengers book in over a year. I dropped New Avengers right at AvsX was starting because I had no interest in the crossover. With both the titles I don't have to figure out how or why. I can just read and enjoy. I also don't have to spend more money to enjoy them.
Wouldn't be hard to do a reboot. Just give the Impossible Man the Infinity Gauntlet like in the What if issue, but this time, he rewrites everything in his image. Oh yah! I would so read that.