No, of course there would be differences. That's part of the reason OMD is so stupid as a status quo. That's not the point. It's not that everything would play out in exactly the same manner as before. Certain parts (anything involving romance) would be cut out, certain lines of dialogue would be changed. But there's nothing about the majority of BND that is fundamentally different with a single or married Peter Parker. That's the point. You can still have Shed (whether you like it or not), you can still have the Gauntlet and Unscheduled Stop. These stories are not fundamentally different with a married Peter Parker, they don't get robbed of their quality or weight because he has a wife at home. And you don't even have to acknowledge her in every issue. Hell, we just had an issue of Spider-Man published that Spider-Man wasn't even in!
Also possibly because such an attitude flies in the face of the customer is always right mentality that we're told to expect in all areas. And while I wouldn't run my business that way if I owned a restaurant, I'll admit I find this less of an issue with creative endeavors. Though it's still a little weird.