As a Puerto Rican male who has gone his entire life without seeing a single super heroic male representative of his culture who wasn't a gang member, given crappy powers, quickly killed off, or all of the above I really really want this book to succeed. I know plenty of fans balk at the idea that having a character that you can relate to on a cultural/background level as being important to some people, but it is. Sure, I identify with Peter Parker, Bobby Drake, Clark Kent, and Bruce Wayne in certain ways, but it's not the same. Yes, Kreisberg doesn't have the best track record, but I'm putting my faith into him. If the book fails then oh well, but if it succeeds at least for awhile I'll be ecstatic.
That said, I'd kind of like to see Aquaman come in at some point as a mentor to Vibe. They're pretty similar in that they've been crapped on for years both by fans and mainstream audiences. I think the two could relate to one another on that level. Maybe Aquaman could give Cisco some valuable meta words of wisdom seeing as how his popularity has definitely increased as a result of Geoff Johns' tenure on the characters' New 52 relaunch.
Also, I kind of hope Vibe has a thing with Stargirl. However, that's probably just me wanting to live vicariously through a fictional fellow Puerto Rican lol