Prepped Bruce is a bit of a beast.
Or worse, in this scenario? 13-on-2 or whatever it is? With one-sided prep for guys like Mysterio, Osborn and Octavius?
Spidey villains would absolutely MUNCH on Bruce. Peter too, for that matter.
Jack of No Trades, Master of Less
PIS/CIS off, it is a total stomp. Any Spidey villain thats considered a legitmate threat should be able to take Spidey with another villain thats a legitimate threat. Take Kraven and Rhino -- vastly different power levels, but Spidey can't take one serious blow from Rhino, and Kraven's traps and martial skill more or less guarantee that Rhino can get that one hit in.
But, if there was prep, and Peter had access to Batman's resources, I think the heroes could pull off a few wins.
Or you can just go complete nightmare mode and pick Carnage and whoever else the Hell you want(Carnage promptly kills them after he's done with Spidey and Bats).
"Tragedy is when I cut my finger. Comedy is when you fall into an open sewer and die." -Mel Brooks
Do it yourself tech support link
~Please allow me to introduce myself, I'm a man of wealth and taste. I've been around for a long, long, year, stole many a man's soul and faith.
So if you meet me, have some courtesy, have some sympathy, and some taste. Use all your well-learned politesse, or I'll lay your soul to waste.
I made Miburo cry on his birthday.
Reached Demon-God Status
My Cat Is Afraid of the Vacuum Cleaner
Carnage no-sells way past class 100 hits, and Mr. Negative hits nearly that hard. There are three people capable of mind-control to various degrees, multiple high-end bullet-timers, three guys who almost can't be killed, two tech wizards, a dude who can TRIVIALLY curb-stomp Spiderman while laughing (Morlun).