In 1983, Harris acquired the assets of the defunct Warren Publishing, including their well-known horror magazines Creepy, Eerie, and Vampirella. Forming Harris Comics in 1985, Harris published a single issue of Creepy (#146), but legal murkiness and a 1999 lawsuit by Warren publisher James Warren resulted in his reacquisition of the rights to Creepy and sister publication Eerie.
In the early 1990s Harris Comics revived Vampirella, publishing Vampirella stories in various series and formats from 1991 to 2007. A number of notable U.K. creators worked for Harris on its Vampirella titles, including Grant Morrison, Gary Frank, Mark Millar, John Smith, Ian Edginton, and Malachy Coney. In January 2007 Fangoria Comics made the announcement that the character Vampirella was now owned by Fangoria, however, in April Harris replied that this was not factual, and began publishing Vampirella Quarterly.
Harris Comics also published a number of non-Vampirella comics in the superhero and science fiction genres. The 2002–2003 imprint Anarchy Studio published manga comics featuring the characters Vampi and Xin. Harris Comics operated until 2008, and in March 2010 Dynamite Entertainment acquired the Vampirella property.