I don't mind it happening outside of continuity, since I've always tried to ignore the UU outside of USM.
Peter's reaction at seeing Gwen was way too understated. Is Pete on mood-altering meds?
The cover seems to show Miles in some sort of distress. Maybe critically injured. Maybe Peter will have to find that Zodiac Key to save his life. Maybe in the process he'll give May and Gwen their Peter Parker back too. Maybe the title of the series will become Ultimate Comics Spider-men.