With regards to a new Spider-Girl, I think that Galina Tsarfin could handle that role quite well. And the sticking point is that she was bio-engineered from the DNA blood samples of Spider-Man and The Black Widow. She could cross over to Earth-616 from her alternate future timeline, as Lyra has done. Here is a link to her history:
http://marvel.wikia.com/Galina_Tsarfin_%28Earth-1078%29
All Marvel has to do is retconned her origin to exclude the 123 kids that she was impregnated with. From there, have her sent into the past on a covert mission to save her future timeline.
Here is a link that talks about her:
http://spidermancrawlspace.com/wwwbo...php?f=4&t=9397



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