Ok I've been kind of thinking about this one for a couple of days & it's probably wrong but this is my theory for what the big thing is in #700
I think it's obvious with the Marvel now teaser & the whole alpha eyes thing in Spidey's costume that it has something to do with Alpha so somehow or another I think Peter & Alpha are gonna somehow do the old mind/body switcheroo. Alpha will be the one in the webs albeit in Peter's body & he'll have to navigate all the relationships Peter has not only in the hero community but in his civilian identity all without giving away the situation he now finds himself in.
So where does that leave Peter In a status quo he hasn't been in a long time & thats back in High School Peter will navigate all the typical high school stuff without somehow not giving away he isn't really Andy & Since Andy will have powers as Alpha by then Peter/Andy will still be able to keep himself in the Hero game albeit with powers he's not use to.
Best I could come up with