I've always thought these two play off each other very well. The only elephant in the room is that Pete isn't going to let Wade get away, obviously; considers him a murderer (and rightly so).
But otherwise, the dialogue between them is always so classic. The stunts Deadpool does to prank Spider-Man are unbelievable.
I'd honestly rather more Spider-Man/Deadpool stories than, say, Spider-Man/Wolverine. It's just more offbeat and fun.