I loved the fact that this show would introduce the villains well before their superpowered origin episode. Also, this show brought Gwen and George Stacy back into relevance (as no one had used them before). I didn't care for lion Kraven, it was mentioned that there were longterm plans for him, and those plans were connected to plans with John Jameson (Man Wolf?)
I also liked the fact that this show was bold enough to change the races of minor characters in order to make it more diverse. I was afraid when the show stared that Randy and Robbie were going to be the token black guys...and they're related! I was pleasantly surprised that we had a couple Asians, Latinos, blacks, and even Indian people in this show. With more people of color in the show it actually seems not forced at all and we don't have a "token".
It's a shame that the series had to end when it did, and on such a rough note as well (which seems to be a plague on Spidey shows). Peter dumped Liz to be with Gwen, but Gwen is guilt tripped into staying with Harry. Marvel must hate Roderick Kingsley though. He appears in this show, it gets cancelled...then in comics they kill him off for Phil Ulrich.
Say what you want about the artstyle, but the designs themselves were pretty solid.