Heck, from the FCBD promo, I'm not even sure Pandora is a villain. Of the three of them, she seems to be the one getting the rawest deal. Judas Iscariot (the Phantom Stranger) gets his bribe to wear about his neck forever, as a reminder of his betrayal. The Lucifer analogue (if there's a myth that closer matches the character, please let me know) who becomes the Question (good thing Ditko isn't around to see THIS, given determinism being atheist at its core) is totally arrogant until his memory is wiped away.
Pandora? She opened a box, that in traditional mythology, needed to be opened. She's historically been a dupe or scapegoat. Making her into a cosmos-shaking villain is going way off the scale. I'm more inclined to think one of that 'jury' is gaming the rest, for their own ends, and using her to do it.