So, whether or not you heeded Slott's plea not to read this issue's preview, you gotta wonder what Spidey and Co's next step is. What we saw in an earlier wordless preview is Sable weeping over her homeland, but that's just the start.
end of spoilers
Spidey stubbornly wants to rescue civilians in harm's way but the pragmatic Widow wants them to move on to the untouched hemisphere and track down Ock. Horizon tries to unclock the satellites but fails, and uses Uatu's idea to track down Ock himself next time he transmits a message. Meanwhile, Mysterio revels with Chameleon in the burning Earth illusion he pulled off, and they send a full-sized Ock in armor replica with Chameleon at the helm. This displeases Ock himself who wants to fight Spidey personally. Sable, still in grief, takes down "Ock", and the gig is up, but Ock remotely takes over and continues the fight. Spidey stops it a second time, reveals his awareness of the illusion to Widow and Cable. Widows talks Chameleon into submission, and Spidey convinces Mystie to bring them to Ock on the grounds that his $2 billion will mean nothing when the Earth burns. Cut to MJ buying the office space where the old WAKE existed (I guessed it right before) for a party she plans to throw a friend. JJJ Sr.'s call to Jonah is cut short as Aunt May also worries why Peter doesn't reply to her calls as theu both want to contact their families in this harrowing time. Back to Spidey, Mystie leads them to his set in Guatemala (complete with a step-pyramid), which is an homage to the Maya prophecies. Ock knocks their plane down and they confront the Octobot-controlled Avengers, Ock's new Sinister Six. As the melee starts, Spidey realizes that all the tech Ock used was based on tech he designed at Horizon which Ock modified, and he blames himself for all the mess