As a fan of OTR/audio drama and comics, I think Decoder Ring Theatre is fantastic and am surprised it's not more well known among comic fans. While I only started listening in January, DRT has been producing their awesome shows since 2005. They have two primary shows - "The Red Panda Adventures" and "Black Jack Justice." Both shows are written, directed and produced by Gregg Taylor, who has also written spin-off novels for each show (3 for "Red Panda," 1 for "Black Jack").
"The Red Panda Adventures" is a pulp-inspired super-hero series. Inspired by characters like the Shadow, the Spirit and the Green Hornet, the Red Panda and his sidekick, the Flying Squirrel, defend 1930s Toronto against the evil plots of the Mad Monkey, Professor Zombie, and a vast array of villains. "Red Panda" runs 12 episodes per season, updated on the 1st of the month (Episode 81 is the latest).
"Black Jack Justice" follows the titular 1940s hard-boiled private detective and his partner, Trixie Dixon, as they investigate everything from murder to missing dogs. The banter is not to be missed. "Black Jack" runs 6 episodes per season, updates on the 15th of each month from September to February (48 episodes to date).
From March to August on the 15th of each month, they run a "Showcase Series" from different writers. Previously they ran a sci-fi series by Matt Wallace called "Deck Gibson, Far Reach Commander" - kind of a Flash Gordon/Buck Rogers type show. Then it was Erik Deckers' private eye comedy "Slick Bracer." Currently they're running the anthology series "Marvellous Boxes" by Tim Prasil. In 2013 it will be "Crogan's Adventures" by Chris Schweizer, based on his Oni graphic novel series.
Some of the "Showcase" stuff is hit-and-miss, but I'm enjoying the current series by Prasil. I haven't heard an episode of Red Panda or Black Jack that I didn't like. Sometimes funny, sometimes serious, but always enjoyable. The closest thing in current comics I can think to compare Gregg Taylor's writing to is Brian Clevinger's writing on Atomic Robo. Smart, witty, fast-paced and fun. I can't recommend Decoder Ring Theatre highly enough.