The cartoons all have their own individual sets of rules and don't have to follow the strict adherence to comic book continuity. (And you missed the 1980 Spider-Man cartoon that actually featured Betty Brant as the main love interest. But everyone forgets that cartoon. And you missed the CGI series that was on MTV. That one was okay. Tied into the Raimi films a little too much. And of course, Unlimited. But we don't talk about that one.)
You've essentially bought into the idea that there are real, long-lasting changes within super hero comics. And at this point, there really isn't. No matter how much it seems like things are different, they aren't. Really.
And there are Superman stories where Lois Lane isn't "the love interest."Well, it's worth noting that based on the issue I started reading that book, that story didn't seem to be over, really. It wasn't a set deal anymore than Betty Brant being the girl in 616 or Gwen and Firestar in Spider-Man loves Mary-Jane. At least, based on Gwen's response to her father when he asks about Peter.
Of course, since they cancelled it(regardless of what Wacker calls it) and replaced it with a new book, we'll never know.
It's also worth mentioning, of course, because it again undermines your position that things will always be a certain way. Marvel Adventures was another new interpretation and no Mary Jane at all. Instead, we get a love triangle between Gwen and some new girl. See previous comments about sample size. The fact that they did it ONCE a certain way is not indicative that they will continue to do it that way.