Perhaps something in the Spider-Men story is what causes Peter to decide to give up being Spider-Man in the 616.
This will be Peter's last year as Spider-Man.
I think that's stretching it a little too much. USM Peter already died, and the public was pretty damn skeptical of Miles' story. If ASM Peter dies, stops being Spider-Man, or something detrimental to the series, there will be too many things the fans will hate. You can't change the Main Marvel universe with something that huge, in my opinion.
We can only guess, though