I could see an Ant Man movie. Focusing on Eric and using Pym as back up/suit creation/science go to guy. Fury and SHIELD in the background would tie it into the Marvel Movie Universe. Honestly, the existence of a big-name known villain isn't necessary. There are dozens of writers who could come up with a main villain. Throiw in a scene of Eric vs Stilt Man. Obvious;y this isn't a powers movie, it's a character study with some awesome camera angles and special effects for shrinking and seeing Eric's use of full size objects.
A Runaways movie could (heck, SHOULD) work. A few teen/youth stars, efforts into a relevant soundtrack, and there's a potential movie franchise. I'd tweak the original story in that instead of making it crystal clear the parents are evil, there remain doubts until the end of the movie. I'd also keep this out of the Marvel Movie Universe. Why? The Avengers or even the FF would seem like a golden parachute for these characters, call Captain America and problem solved. Without the Marvel Universe, the kids need to solve the problem of if their parents are heroes, villains, or a mix by themselves.
I'm thinking old school when i hear GotG. Vance Astro flying out to Alpha Centauri, an opening almost ripped off from Heston's Planet of the Apes and a landing almost ripped off from Wizard of Oz. I'm assuming Avatar like tech could handle the other characters and aliens. Moot thoughts as the originals aren't being used, I guess.
Hawkeye and the Black Widow, heck even Daredevil and the Black Widow would work.
Dr Strange? I'd love to see it, but I'm not sure what might work.