Talent Manager C.B. Cebulski joined the crew as they discussed the prelude #0 issue. "One of the things we were excited about all the time from when we started 'AvX' [was the relationship between Scarlet Witch and Hope,]" Aaron said. Alonso added, "If you're asking why we picked these two...years ago, Wanda said 'No more mutants' and decimated the mutant population. A few years later, a little girl named Hope showed up and said 'Hell yeah, mutants!'"
Okay, we are here hinted that Hope may be the result of Wanda, from " No More Mutants", as a kind of embedded failsafe. Get rid of all the mutant powers, but, leave a seed in place so the mutants can start up again.
If that is the case, then Wanda will be the focus of the mutants on ethical grounds and on trigger mechanism grounds - "Wanda, if you can make Hope, make more Hopes".