Guardians of the Galaxy? How would I do it so it doesn't get cancelled? Well, here's my plan:
First step - Make it enticing
In order to make it enticing, I'd have to gauge reader responses. How would I do such a thing? Have the characters that will make up the Guardians line-up show up throughout the Marvel U, in the background of some really big storylines running across each book, but also making sure that they don't blend in completely in the background.
How? Well, have a scene in The Avengers where Spider-Man is walking into a room where Captain America and Iron Man are looking at a video screen with Nova and Quasar, talking about something seriously going wrong and how they would not be in contact with the Avengers for a while. Then show the Kid Gladiator talking to Warbird about how they'd should have left the mudball to help Gladiator in the war that is in full-swing in some distant corner of the galaxy. Have Captain Marvel show up in Defenders to meet up with the Surfer and leave the comic within the first 3 panels, with a quick conversation blip about how they are both needed elsewhere.
See how the kind of reaction this gets. Then do a teaser image of the this story showing up in the pages of a new comic coming up.
Second step - Show some dedication and support
Some newbie writer along with an average artist on the new GotG book? Ok, it might sell. But get some names on it and make promises about how great it will be. Really show that this book is here to stay. Explain that the book has a 2 year plan, right from the begining because this is how great it is going to be. It will stick around for 24 issues, because that's how big the story is. In order to tell this story, you're going to have some really big names on it. DnA may not be big names, but given enough love, they can very well be the guys who brings you the next IT book. Give them a consistent and great roster of artists that will tell each story and see what that does to the fans.
Third Step - Line up that beats all line up
Yeah, Nova and the Annihilators are powerful, but they sure do have some boring personalities on that team. You wanna make the roster pop? You gotta have the powerhouses and the quirky characters. Imagine Star Trek with Captain Kirk and 4 Datas and 3 Qs. Imagine Lord of the Rings trio of Aragorn, Legolas and Gimli being replaced by Aragorn, Gandalf, and Treebeard? That's just NOT how you do it. You gotta make sure there are some great cosmic characters in there. That means:
Captain Marvel (gotta have the new lady powerhouse)
Kl'rt the Super Skrull
and for the hell of it...toss in Blue Marvel, because there just aren't enough super powerful black guys in space, dammit!
Fourth step - Make it relevant
That one thing Axel Alonso said that I still have a problem with...ongoing, in-continuity average books will always sell better than really well told, well illustrated limited series. In order to make Guardians relevant, you have to have things that play a factor in the larger Marvel U. If there's an Annihilation level threat that's plaguing the Marvel U, there's going to have to be some casualties, changes in allegiance, dramatic alteration of tactics based on desperation, and ultimately a payoff that matters to the larger Marvel U with lasting changes.
Those are my ideas.