I use Doc Strange mainly for healing. Since you have to wait I think 2-3 rounds before Iron Fist can heal again.
Would use Iron Fist and Colossus. But a lot of people are using tacticians and infiltrators. At least the ones I face.
That and mostly Human Torch.
My weapons for my agent: Cryotonfa 27, Pyro Tonfa 18, and then Brutal claw 34. I know the tonfas are bad but they're great for counter attacks IMO. Least till I get to lvl 60 or can reforge them to make them stronger. Brutal claw has ravaged.
Should I just make my PVP team Cyke and Colossus then? It won't let me hit Chapter 8 till I get 5 more mission stars. The problem is my energy though.
Oh, as far as my heroes are concerned. I don't really have any of their alternate costumes.