By the very nature of comic books, there are inevitably going to be loose ends that never get tied up, or storylines that never get resolved. Would like to hear some of your most memorable instances.
A recent one for me was within Fear Itself. I was looking forward to seeing both the Thing and the Hulk come to the final battle with the Serpent. Obviously, both had a fair reason to be ticked off with the Serpent. It's been awhile since Ben Grimm really lost his cool on someone, and it's always good to see Hulk unleash on someone who really deserves it. Yet, the final battle came and went and neither showed their face! The Thing seemed to pretty much shrug his shoulders after Franklin cured him and go "Well, that's that, back to the FF!" spoilers:
end of spoilers
(Although he just showed up in Fearless #4, so perhaps that will provide closure.)