Apparently, the Marvel badguys ARE all coming together pretty soon. Daredevil(another comic under the Stephen Wacker umbrella) revealed that Hydra, AIM, The Zodiac Cartel, etc are all forming this big supercrime group. Something like that may be a real force to be reckoned with in the MU, especially with whatever secret "cargo" they've been shipping.
In fact, I'm willing to bet they are connected/referenced in this upcoming Sinister Six story.
The one thing about the Six that always bothered me, though, is that it never seemed like Ock sat down and selected a team based on complimenting strengths and weaknesses. He pretty much got whomever was available off his rolodex.
Went with Juggs because you need muscle... he use to be about money for muscle and i know bullseye is. I know daken craves power but so does Doc Ock.
Shocker and hobgoblin are all about the money and the fun of the job. (obviously im referring to hobgoblin phil or macendale... Kingsley needs no team ups.)
Makes sense, Juggernaut being the Rhino, Daken the right hand man, and Bullseye being Kraven with each having their score to settle on Spider-Man from past confrontation. Sounds great, wouldn't put it past Daken to undermine Doc Ock's leadership.