But then there's that other bit:
Karen is a "little bit different". Not Karen Starr tech mogul? Is she really something like Karen Starr DEO agent? Is that really her on the cover to Voodoo #2? There's nothing that says she can't appear in more than one title, though I'll note that parts of the rest of the panel seem to rule out anything to do with either JLI or Justice League.
And there's the bit that there's a connection between Karen and Michael Holt that will be revealed later.
What that last is I have no idea.