Should make sense, but you will want to just take it slow. Some events in B.P.R.D. will mean very little to you (or not have the same impact) until you've read upto-and-including Vol 5 (I mean the 5th set of stories, not the 5th library edition) of Hellboy, Conqueror Worm.
EDIT: Update - Just got my pre-release notice for Omnibus 4. Huzzah!