And asterisks pointing to "plot-points" - how often does that happen? I would think most usually asterisks denote in which title somebody or something appeared or got mentioned before - but not as proving too vital to the plot of the story-at-hand?
And it will be good to be aware how Hellboy's own perspective would be or not for an event, but the question is: would such get necessarily spoiled, by reading stuff out of order for a first time?
I certainly would not think so, since any new reading of titles fitting any kind of an order, might bring about new perspectives or takes or reading experiences for me.
(This is why) I'd feel people shouldn't feel too skiddish about spoiling the reading for themselves.