Here's my thoughts on what to do with two female Spider super villains.
Female Scorpion She thrash's humans, and serves as a enforcer for a minatory Drug Kingpin.
Shriek She deals cocaine, crack cocaine, and other negative drugs. Also it would be hell if she was in Yankee Stadium during a Yanks Red Sox game because she could make a disastor. Come one she can bring out the darkness in people don't let that go to waste.