Pinky & The Brain? Maybe. I gotta admit, I prefer updating human characters more than funny animals.
Space Ghost? Probably something Jan and Jace related. :)
And for my next trick.... this should be popular on these boards...
Spider-Man And His Amazing Friends: "Chillin' In The Crime Lab"
Ah, the Spider-Friends. One of my favorite cartoons as a kid... probably because Spider-Man, Iceman and Firestar were so much cooler and funnier than the Superfriends. And remember how their apartment converted into a high-tech crime lab with the twist of that football trophy? Well, here it is -- the Spidey Pals - Pete, Bobby, Angelica and even Ms. Lion - in their civvies. I took the character designs from the show and gave 'em some more modern looks. Spider Friends.... go for it.