I don't have any spoilers at this point beyond what we see in the various trailers and the casting news.
But the plot appears to be as follows:
A Romulan named Nero travels back in time to disrupt the original series. Spock (Leonard Nimoy) follows in hot pursuit but is too late. History is disrupted. Young Kirk has lost his way. What follows is the original series crew attempting to salvage their destiny in the face of an enemy who has already destroyed their future.
I know a lot of people are deriding the time travel concept and saying it's overdone in Star Trek but I think it's thematically essential to the movie I'm envisioning, which would be good even if it weren't Trek.
I think this movie is going to be about what happens when when a person has a bright future taken away from them and then spits in the eye of fate and says they want it back.
I don't think this is a remake in the way some people imagine and I don't think it's a total invalidation either. I think Kirk and Spock are presented with their classic lives, told they can never live up because history has already changed beyond repair and then rise to the challenge, insisting that the details don't NEED to be intact, that they can make it all happen even in spite of setbacks.
I think that's a more resonant message than a pure origin story or a pure sequel or even a pure remake. But that the whole point of this movie is to contrast the original series with a darker world and have the Enterprise crew insist that they can remake the future that should be impossible for them.
So in a sense, it would wipe out TNG, DS9 and Voyager... But if we believe in Kirk and his crew then all of the other stuff remains true because we want to believe that he can salvage it, even in a new history.
If it is as I suspect, this is all about having your future stolen and then demanding it back, which has never been done before in Star Trek, where time travel usually relies on the time travelers to set history right, not so much the people in the past. If you look at First Contact, that's really about the TNG crew dragging Cochran into the future.
Whereas this? I think this will be about Kirk, at a low ebb in his life, deciding that he can fix the future even without a clear road map. (Although, my prediction is that old Spock will mindmeld with young Spock, providing a partial road map and making Spock the guiding voice in reassembling a future that has already been destroyed.)