Okay, this time around let's do the one writer/one artist thing using only writers and artists that haven't worked on Amazing Spider-Man in the last year (Slott/Guggs/Gale/Wells/Kelly/Waid/Reed/Stern are out, for example).
And just to make things interesting, let's leave out JMS, Peter David, and Roberto Aguirre-Sacasa, as they've all had recent runs.
Marvel Team-Up by Mark Millar and Bryan Hitch
All-star creative team, which would certainly help the book sell. Millar's an "event" writer, so if he took that approach to this book it could certainly be interesting, and Hitch is an artist that can draw the hell out of just about any character (though his Spidey is sometimes a bit off). And the likely delays wouldn't be as big a deal in a book that isn't too continuity-tied.
Web of Spider-Man by Mike Carey and Stuart Immonen
Carey's great at exploring and creating worlds around a character (see his Felix Castor books) and Stuart Immonen is an artistic chameleon, changing his style to suit the story. He also draws a great Spidey.
Spectacular Spider-Man by Ed Brubaker and David Aja
Brubaker is as much a character guy as he is a crime guy, so a book that focuses both on Peter and his ensemble as well as more street-level stories is perfect for him. Aja's like a darker Marcos Martin and can draw action without losing any of the storytelling.
Amazing Spider-Man by Kurt Busiek and Mark Bagley
Busiek's more than earned a shot at the flagship Spidey book, and teaming with one of the best Spidey artists (and frequent collaborator) is a no-brainer.