You know with Batman, it's the Joker
You know with Superman, It's Luthor.
But with Spider-Man, I'm not too sure. (I'm sure someone is going to joke around and say Joe Quesada) but all jokes aside, I know it comes down to Norman Osborn (The Green Goblin), Venom (Eddie Brock) and Dr. Octopus. When I was a kid, I thought it was Doc Ock because it always seemed like Spider-Man was up against Doc Ock in one form or another and they had that chemistry that made them great foes of one another. But as I got older, I was introduced to the Green Goblin and all of the major damage he's done to Spider-Man over the years, has to count for something. Of course, there's always Venom and he always seemed like a contender for the top villain spot as well. So I'm just curious, who do you regard as Spider-Man's greatest foe?