It takes place after the final story arc.
The story involves Cassie, after the events of the HACK/SLASH series, trying to live a normal life. Of course things won't be normal for long as a Deadite attack forces her back into action. Used to working with a partner, this time Cassie will find herself teaming up with Ashley J. Williams. The question is, can they get along in order to complete their quest to find the stolen pages from the Book of the Dead.