Non-mutant team book- New Avengers and Young Avengers
X-book- Grant Morrison's run on New X-Men is excellent, X-Factor is starting soon which will kick ass.
Comedy title- Cable and Deadpool, bay-bay
Detective/Noir/Action title- DAREDEVIL! Bendis' run is amazing, Brubaker's coming on in a few.
A-lister title- Captain America. Just awesome.
Now THAT'S a pull-list. Feel free to try Astonishing X-Men, it has wide appeal. Don't touch Black Panther.