Okay, it's probably unlikely that a "She-Hulk" movie will get made, unless Hulk II proves to be a mega-sucess and either Jen gets her own movie or a spin-off.
Apparentally during the time of the Bill Bixby Hulk TV movies (Late 80s) there was discussion of a She-Hulk project, and apparentally a make-up test was done with Bridgette Nielsen (Rocky IV, Red Sonja, Beverly Hills Cop 2 and a few D-list celebreality shows etc.) but the film never came off the ground.
A She-Hulk movie would probably have to be sort of toungue-in-cheek, like the majority of Shulkie comics. Unlike her cousin, it's fairly easy to realize She-Hulk by just green body paint, although it might be a challenge to contrast her to Jennifer Walters with it still being the same actress, although they could make her like Michelle Pfeiffer's Catwoman, who seemed like a totally different actress after her 'transformation'. That being said, I think Angelina Jolie would make a pretty good She-Hulk.
Of course the movie will probably never be made, but who knows...