(Subject line is pretty self-explanatory, I think :) )
The moment that comes immediately to mind as a time when I laughed out loud, not only the first time, but every time that I read it, was the following scene from USM:
I'm paraphrasing from memory, and it's been some months since I last read it, so it's probably not completely accurate. I think it's located at the beginning of the "Deadpool" storyarc. It's the first time we meet "The Ringer."
The Ringer: I'm The Deadly Ringer! Straight up, I'm from Waldorf, Maryland!
Spidey: What? What does that even mean? Am I dreaming? This feels like it might be a dream. No more jalapeno cheese nachos before bed for me.
The Ringer: You gonna be laughing out the side of your face by the time I'm done with you!
Spidey: Hey, slow down with the street talk... I'm still hung up on the part with you bragging about being from Maryland! I gotta... did I miss a memo? Did Maryland become cool?