I was reading "Claws" earlier, and it got me thinking: the White Rabbit is such a fantastic, hilarious villain, but is hardly ever used. She, like most of the Spider-Man villainesses, are always overlooked and passed by for other villains such as Electro or the Rhino. Granted, you can't really compare the White Rabbit to Rhino, but my God, where's the gender equality?
Spider-Man has some great villainesses, such as:
Princess Python, who is one of the first females encountered by Spider-Man. However, because she belongs to the Circus of Crime (or at times, the Serpent Society), she never really could pose a credible threat as a solo villainess.
The White Rabbit, as mentioned before. However, I think she'd make a much better antagonist for, say... Squirrel Girl! In my dreams, Squirrel Girl has her own series and the White Rabbit is her major enemy.
Scorpia, although she takes the name from a male villain, she is quite a badass in her own right. And I loved her most recent appearance in the Spidey/Black Cat mini, she should definitely be used more.
Stunner, one of the most interesting and complex villains Spider-Man has faced, despite only appearing in 10-something issues. I loved the fact that she was secretly a shy, overweight girl, because obviously there's a lack of realistic women. They could easily have her "awaken" from her coma and cause a little trouble for Spider-Man.
Calypso, though I haven't read much of her honestly. I heard she died again, but I mean, with a character like her, it'd be easy to bring her back.
Others like Shriek, Delilah, Shathra, and Lady Octopus are pretty neat, but they don't really stick out in my mind, personally. I just think the Spider-Villainesses should get some love. Have overused villains like Venom and the various Jack O' Lanterns sit out a few battles and give it to the ladies for once!