So if and when the Pro-reg forces win the Civil War, does this fundmentally change the Marvel Universe. I mean under the said rules of Registration it will be impossible to have the same superhero enviroment as before the SHRA.

Example.
Peter Parker is bitten by a radioactive spider and gains superhuman abilities. He registers as Peter Parker/Spider-man and as he is a minor he goes into a SHIELD run superhero training program. He never meets Mary Jane. Ben doesn't die. etc..etc....