I'll not go into a page by page breakdown, but the issue basically goes like this.
Reed is transporting Wildstreak into the negative zone. I thought there was a big transport portal used in Frontline, but here we have capsules that are used which don't have any guard rails around them but apparently explode if metal (or metal clad cape killer agents) touches them. Reed claims he needs to calibrate each transport to counter the super powers of the person inside. An easier method would have been to take off her exo-skeleton which Wildstreak uses just to walk. The poor girl is a cripple.
Reed is a bit more human here than in CW proper, he's forcing himself to stay focused on numbers and calculations instead of allowing any empathy for the people he's sending to the prison. It seems he's having some internal struggles with the whole process.
Cape Killer touches transport, transport breaks, Wildstreak runs. With the help of the Invisible Woman she escapes (as seen in the previews). Reed knows Sue did it, they argue. This is the real arguement they'd have, not the sweet letter and night of lovemaking in CW4. In the letter she says argueing would be pointless, but here they do argue and Sue 'leaves'. Guess she came back and left again? She does bring up the Nazi word (a customer of mine mentioned that three members of the Nazi party were voted into the government in Germany. Is this true? Yikes!)
Reed's excuse to Sue is that he's trying to protect his family from being ruined, their well being pulled out from under them by the government. Sue basically says he's not the man she married because HER Reed Richards wasn't ever afraid of anything.
Enter Ben. Ben claims that he's a Patriot and won't fight his own country (you know, like last year or any other time he went against the military/government?) so he's going to France since staying makes it look like he supports the Act. He's a multi-billionaire. If he really didn't LIKE it he should use his money and influence to contest it. But oh well, running away seems to work better with Millar's story.
Then we get a replay of Stark and Tony's visit to see the Negative Zone. I didn't read the ASM version, this one doesn't show the prison, but we do get Reed's Uncle story again (which only seems to affect him now, not all the other times he went against the government and status quo), and Peter says his Uncle sounded like a great man that he'd really like to meet. He leaves Reed with, 'but you LOVED him.' as a very well struck knife in the heart. Of course Stark used listening devices to spy on the entire private conversation. Not sure if that was depicted in Spider-Man or not.
Aside from the glaring errors concerning Wildstreak (who made her debut in FF Annual #26 helping Ben and Psi-Lord against Dreadface and the artist was..well. Like a BAD version of Rob Leifeld. If you can possible imagine that) the issue did a lot to save face for Reed. He has doubts, Sue leaves in a huff. As he's trying to bury himself deep in the numbers and calculations again to shut down his soul he begins going over the monetary damages to their HQ that Sue left behind in their arguement. All I could think of was a Visa Card commercial, "Water Damage to Multiple floors:$789,000. Only one more issue until Dwayne McDuffie begins writing this series: Priceless."