Well, it's finally here! I'm shocked there's no thread on it so far, so I may as well get the ball rolling. ;)
So, we now know that Aunt May and Richard Parker are the real deal. Gwen is Carnage. Mary Parker and Eddie Brock Sr. are both dead. MJ has been transformed into...well, we don't know yet (I still think it's a Goblin-type creature). And there's apparently another, six-armed Spider-Clone running around in a nifty looking black costume. Not to mention that Nick Fury is now going up against Spidey and Carnage with a large number of Spider-Slayers, and Aunt May is having a heart attack.
Whew! That's a lot for one issue!
Now, for some speculation.
What did the new Spider-Clone mean when he said "this isn't what we were created for" when attacking "Kaine?" Based on what I've seen and read, and I think I actually posted this before a few weeks ago, it seems obvious now that Fury is behind the mass production of Spider-Clones. He confiscated Curt Conners' lab experiments, which means he had access to Pete's blood and DNA. And, as I know I stated before, it seemed very odd to me that Fury referred to his machines as "Spider-Slayers." He had them made as an insurance policy to keep the clones under control. It looks like Fury couldn't quite get an army of Captain Americas, so he decided to settle for an army of Spider-Men instead.
Man, there's still so much left unanswered. I'll be glad when this whole thing is finally over and we can observe the aftermath. It's looks like the status quo is going to be just as messed up as 616's Spidey when this is all said and done.